New Phenolic Compounds with Anti-adipogenic Activity from the Aerial Parts of Pulsatilla koreana

作者：Liu Qing; Ahn Jong Hoon; Kim Seon Beom; Hwang Bang Yeon; Lee Mi Kyeong^*

来源：Planta Medica, 2012, 78(16): 1783-1786.

DOI：10.1055/s-0032-1315368

• Pulsatilla koreana
• Ranunculaceae
• pulsatillosides A-C
• adipocyte differentiation

Three new phenolic compounds, pulsatillosides A (1), B (2), and C (3), were isolated from the aerial parts of Pulsatilla koreana, together with two known flavonoid glycosides, trans-tiliroside (4) and kaempferol-3-O-beta-glycoside (5). The structures of the isolated compounds were determined on the basis of spectroscopic analysis including 1D, 2D NMR and HR-MS. Among the isolated compounds, compounds 1-3 significantly inhibited adipocyte differentiation as measured by fat accumulation in 3 T3-L1 cells using Oil Red O staining.

• 出版日期2012-11