科研之友
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摘要
"Ms. B" is a 45-year-old married premenopausal woman who was diagnosed with major depressive disorder 10 years ago and then successfully treated for 12 months with fluoxetine (20 mg/day) without significant side effects. She remained free of depressive symptoms for the next 8-9 years. One year ago, she was diagnosed with estrogen receptor-positive invasive breast cancer and underwent treatment with surgery, followed by chemotherapy, and then radiation therapy. Ms. B. has been treated with tamoxifen (a selective estrogen receptor modulator) for the past 6 months to reduce the likelihood of breast cancer recurrence. She has tolerated tamoxifen relatively well, except for moderately bothersome hot flashes, for which she has received no pharmacotherapy. Recently, however, she developed recurrent depressive symptoms and sought treatment from her psychiatrist. What pharmacologic agents are effective against both depression and hot flashes in women with breast cancer? Would any of these agents compromise the efficacy of tamoxifen or increase its toxicity through a drug-drug interaction?
- 出版日期2008-10
