科研之友
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摘要
The first example of a Lewis acid catalysed asymmetric hydroxyamination of beta-ketoesters with nitrosocarbonyl compounds generated in situ was accomplished. The combination of a catalytic amount of Mg(OTf)(2) with a chiral N,N'-dioxide ligand provides highly substituted quaternary beta-keto amino acid derivatives in high yields (up to 97%) and enantioselectivities (up to 96%). Regioselectivities (N- vs. O-attack) are uniformly high for all substrates (>20 : 1).
- 出版日期2014
