Antibody molecules discriminate between crystalline facets of a gallium arsenide semiconductor

作者：Schnirman Arbel Artzy; Zahavi Efrat; Yeger Hadas; Rosenfeld Ronit; Benhar Itai; Reiter Yoram; Sivan Uri^*

来源：Nano Letters, 2006, 6(9): 1870-1874.

DOI：10.1021/nl0607636

Seamless integration of biomolecules with manmade materials will most likely rely on molecular recognition and specific binding. In the following we show that combinatorial antibody libraries, based on the vast repertoire of the human immune system, can be harnessed to generate such binders. As a demonstration, we isolate antibody fragments that discriminate and bind selectively GaAs ( 111A) facets as opposed to GaAs ( 100). The isolated antibodies are utilized for exclusive localization of a fluorescent dye on ( 111A) surfaces in a structure comprising a mixture of ( 100) and ( 111A) surfaces. The potential importance of structure rigidity to facet recognition is suggested vis-a-vis published experiments with short and longer peptides.

• 出版日期2006-9-13