A naphthalene diimide dyad for fluorescence switch-on detection of G-quadruplexes

作者:Doria F; Oppi A; Manoli F; Botti S; Kandoth N; Grande V; Manet I*; Freccero M
来源:Chemical communications, 2015, 51(44): 9105-9108.
DOI:10.1039/c5cc01536g

摘要

A non-fluorescent naphthalene diimide (NDI) dimer, conjugating red and blue NDI dyes, becomes red/NIR emitting upon G-quadruplex binding. The fluorescence lifetime which is significantly different for the complexes, the G-quadruplex/dimer and the weakly emitting ds-DNA/dimer is the key feature for the development of new rationally engineered G-quadruplex sensors.

  • 出版日期2015