Anticonvulsant and Neuroprotective Effects of Oligosaccharides from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes)

作者：Aguirre Moreno Alma; Villeda Hernandez Juana; Campos Pena Victoria; Herrera Ruiz Maribel; Montiel Elizur; Tello Isaac; del Rio Portilla Federico; Rodriguez Veronica; Leon Rivera Ismael^*

来源：International Journal of Medicinal Mushrooms, 2013, 15(6): 555-568.

• medicinal mushrooms
• Lingzhi or Reishi mushroom
• Ganoderma lucidum
• oligosaccharide
• neuroprotective
• anticonvulsant

An oligosaccharide fraction isolated from the mycelium of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidwn (GLOS) was separated by size-exclusion chromatography. The chemical structure of GLOS consists of a disaccharide repeating unit [-4-beta-1-Galf(1-6)-O-(beta-Glcp)-1-](n) (n=3,4). In addition, this study was undertaken to determine the possible anticonvulsant and neuroprotective effects of GLOS (10-80 mg/kg) on kainic acid (KA)-induced seizures. The behavioral alterations and histopathology of hippocampal neurons were studied. Our results show that GLOS inhibited convulsions in rats from KA-induced seizures, reduced the degeneration pattern in the CA3 region of rats, decreased astrocytic reactivity, and reduced the expression of IL-1 beta and TNF-alpha induced by KA. These results indicate a potential anticonvulsant and neuroprotective effects of GLOS.

• 出版日期2013