Associations between Dietary Patterns, ADR2 Gln27Glu and ADR3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study

作者：Nanri Hinako^*; Nishida Yuichiro; Nakamura Kazuyo; Tanaka Keitaro; Naito Mariko; Yin Guang; Hamajima Nobuyuki; Takashima Naoyuki; Suzuki Sadao; Nindita Yora; Kohno Michiko; Uemura Hirokazu; Koyama Teruhide; Hosono Satoyo; Mikami Haruo; Kubo Michiaki; Tanaka Hideo

来源：Nutrients, 2016, 8(9): 545.

DOI：10.3390/nu8090545

• dietary pattern
• factor analysis
• -adrenergic receptor (ADR)
• polymorphism
• triglyceride

Interactions between dietary patterns and 2 -adrenergic receptor (ADR) gene polymorphisms (ADR2 Gln27Glu and ADR3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35-69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADR3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADR polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADR3 polymorphism modifies the effects of the bread pattern on triglyceride levels.

• 出版日期2016-9
• 单位RIKEN