An Efficient Thiol-Ene Chemistry for the Preparation of Amphiphilic PHA-Based Graft Copolymers

作者：Le Fer Gaelle; Babinot Julien; Versace Davy Louis; Langlois Valerie; Renard Estelle^*

来源：Macromolecular Rapid Communications, 2012, 33(23): 2041-2045.

DOI：10.1002/marc.201200485

• amphiphilic graft copolymer
• polyhydroxyalkanoate
• thiol-ene chemistry

We present a straightforward method to prepare amphiphilic graft copolymers consisting of hydrophobic poly(3-hydroxyalkanoates) (PHAs) backbone and hydrophilic a-amino-?-methoxy poly(oxyethylene-co-oxypropylene) (Jeffamine (R)) units. Poly(3-hydroxyoctanoate)-co-(3-hydroxyundecenoate) (PHOU) was first methanolyzed to obtain the desired molar mass. The amino end groups of Jeffamine were converted into thiol by a reaction with N-acetylhomocysteine thiolactone and subsequently photografted. This one-pot functionalization prevents from arduous and time-consuming functionalization of the hydrophilic precursor or tedious modifications of PHAs, thus simplifying the process. The amphiphilic nature of modified PHAs leads to water-soluble copolymers exhibiting thermoresponsive behavior.

• 出版日期2012-12-13