Activity of Ceftolozane-Tazobactam and Ceftazidime-Avibactam against Beta-Lactam-Resistant Pseudomonas aeruginosa Isolates

作者：Humphries Romney M^*; Hindler Janet A; Wong Beringer Annie; Miller Shelley A

来源：Antimicrobial Agents and Chemotherapy, 2017, 61(12): e01858-17.

DOI：10.1128/AAC.01858-17

• ceftazidime-avibactam
• ceftolozane-tazobactam
• MIC
• Pseudomonas aeruginosa
• susceptibility testing

Ceftolozane-tazobactam (C/T) and ceftazidime-avibactam (CZA) MICs were evaluated for a collection of 309 beta-lactam-resistant isolates of Pseudomonas aeruginosa recovered from three institutions in the area of Los Angeles, CA. Overall, 12.0% of isolates were susceptible to imipenem, 15.9% were susceptible to meropenem, 20.7% were susceptible to piperacillin-tazobactam, 24.6% were susceptible to ceftazidime, 25.9% were susceptible to cefepime, 72.5% were susceptible to C/T, and 61.8% were susceptible to CZA. Among C/T-resistant isolates, 9.1% were CZA susceptible, whereas 36.4% of CZA-resistant isolates were susceptible to C/T.

• 出版日期2017-12