科研之友
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摘要
A practical and environmentally friendly organocatalytic one-pot strategy designed to furnish the hetero-Diels-Alder products was shown to be effective in the preparation of disubstituted tetrahydropyranones in a highly selective manner. (S)-1-(2-pyrrolidinylmethyl)pyrrolidine catalyzed an asymmetric assembly reaction involving a hetero-Diels-Alder reaction between alkylidene- and arylidene-acetones generated in situ from Wittig reactions with diethyl ketomalonate to furnish the substituted tetrahydropyranones in moderate to very good yields with moderate enantioselectivity.
- 出版日期2016
