An efficient partial synthesis of 4 '-O-methylquercetin via regioselective protection and alkylation of quercetin

作者：Li Nian Guang; Shi Zhi Hao; Tang Yu Ping^*; Yang Jian Ping; Duan Jin Ao

来源：Beilstein Journal of Organic Chemistry, 2009, 5: 60.

DOI：10.3762/bjoc.5.60

• alkylation
• high yield
• 4 '-O-methylquercetin
• partial synthesis
• regioselective protection

An efficient partial 5-step synthesis of 4'-O-methylquercetin from quercetin in 63% yield is reported. This strategy relies on the selective protection of the catechol group with dichlorodiphenylmethane in diphenyl ether as solvent and on the selective protection of the hydroxyl groups at positions 3 and 7 with chloromethyl ether.

• 出版日期2009-11-4
• 单位南京中医药大学; 中国药科大学