FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation

作者：Li, Jun-yan; Wang, Nan; Khoso, Mir Hassan; Shen, Cheng-bin; Guo, Meng-ze; Pang, Xin-xin; Li, De-shan^*; Wang, Wen-fei^*

来源：Inflammation, 2018, 41(3): 751-759.

DOI：10.1007/s10753-018-0729-3

• FGF-21
• THP-1 cells
• IL-10
• LPS

Fibroblast growth factor 21 (FGF-21) has been previously judged as a major metabolic regulator. In this paper, we show that FGF-21 has a potential role in anti-inflammation and immunoregulation. In vivo, treatment with exogenous FGF-21 can alleviate LPS-induced inflammation. In vitro, FGF-21 inhibited LPS-induced IL-1 beta expression in THP-1 cells. Furthermore, besides the NF-kappa B pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway. This study clearly indicates that FGF21 can be used as an attractive target for the management of inflammatory disorders. This piece of research indicates that FGF-21 could have much value in the management of inflammatory disorders.

• 出版日期2018-6
• 单位东北农业大学