alpha-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression

作者:Lobato Kelly R; Cardoso Chandra C; Binfare Ricardo W; Budni Josiane; Wagner Cristiane L R; Brocardo Patricia S; de Souza Luiz Felipe; Brocardo Caroline; Flesch Samira; Freitas Andiara E; Dafre Alcir L; Rodrigues Ana Lucia S*
来源:Behavioural Brain Research, 2010, 209(2): 249-259.
DOI:10.1016/j.bbr.2010.02.002

摘要

This study investigated the antidepressant potential of a-tocopherol, the most active and abundant form of vitamin E, in the forced swim test (FST) and tail suspension test (TST). The acute oral treatment with a-tocopherol at the doses of 30 and 100 mg/kg reduced the immobility time in the FST and in the TST. A single i.c.v. administration of a-tocopheryl phosphate, a water-soluble analogue of a-tocopherol, also reduced the immobility time in the FST (0.1 and 1 nmol/site) and in the TST (0.1 nmol/site). In addition, the long-term treatment (28 days) with a-tocopherol (10 mg/kg, p.o.) significantly reduced the immobility time in the FST. Moreover, a subeffective dose of alpha-T (10 mg/kg, p.o.) potentiated the effect of fluoxetine (10 mg/kg, p.o.) in the FST. The long-term treatment with a-T was able to increase the glutathione (GSH) antioxidant defense system, while the acute treatment was not. The long-term treatment with a-tocopherol (10 mg/kg) increased the GSH levels in the hippocampus and in the prefrontal cortex and increased the glutathione peroxidase and glutathione reductase activity in the hippocampus (10 mg/kg) and in the prefrontal cortex (10-100 mg/kg). The long-term treatment with fluoxetine (10 mg/kg, p.o.), a positive control, was also able to increase the GSH levels in the hippocampus, but failed to alter the activity of both enzymes. Besides the specific antidepressant-like effect, long-term, but not the acute treatment with a-T, especially in the doses that produced an antidepressant-like effect (10 mg/kg), improved the antioxidant defenses in the mouse hippocampus and prefrontal cortex, two structures closely implicated in the pathophysiology of depression.

  • 出版日期2010-6-19