A novel compound of triphenyltin(IV) with N-tert-butoxycarbonyl-L-ornithine causes cancer cell death by inducing a p53-dependent activation of the mitochondrial pathway of apoptosis

作者：Girasolo Maria Assunta^*; Tesoriere Luisa; Casella Girolamo; Attanzio Alessandro; Capobianco Massimo L; Sabatino Piera; Barone Giampaolo; Rubino Simona; Bonsignore Riccardo

来源：Inorganica Chimica Acta, 2017, 456: 1-8.

DOI：10.1016/j.ica.2016.11.012

• Triphenyltin(IV)
• Boc-Orn-OH
• NMR
• Antitumor agents
• Apoptosis

The triphenyltin(IV) compound with N-tert-butoxycarbonyl-L-ornithine (Boc-Orn-OH), [Ph3Sn(Boc-Orn-O)], was synthesized and characterized by elemental analysis, FT-IR, solution H-1, C-13 and Sn-119 NMR and ESI mass spectrometry. The organotin(IV) compound inhibited at very low micromolar concentrations the growth of human tumor cell lines HepG2 (hepatocarcinoma cells), MCF-7 (mammary cancer) and HCT116 (colorectal carcinoma) while it did not affect the viability of non-malignant human-derived hepatic cells Chang. The mechanism of the antiproliferative effect of Ph3Sn(Boc-Orn-O), investigated on human hepatoma HepG2 cells, was pro-apoptotic, being associated with externalization of plasma membrane phosphatidylserine, chromatin condensation or fragmentation and mitochondrial dysfunction as well as with increase of p53 levels.

• 出版日期2017-2-24