Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy

作者：Nirengi Shinsuke; Homma Toshiyuki; Inoue Naohiko; Sato Hitoshi; Yoneshiro Takeshi; Matsushita Mami; Kameya Toshimitsu; Sugie Hiroki; Tsuzaki Kokoro; Saito Masayuki; Sakane Naoki; Kurosawa Yuko; Hamaoka Takafumi^*

来源：Journal of Biomedical Optics, 2016, 21(9): 091305.

DOI：10.1117/1.JBO.21.9.091305

• near-infrared spectroscopy
• noninvasive
• capsiate
• brown adipose tissue
• F-18-fluorodeoxyglucose positron emission tomography combined with computed tomography

F-18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/ CT)is widely used as a standard method for evaluating human brown adipose tissue (BAT), a recognized therapeutic target of obesity. However, a longitudinal BAT study using FDG-PET/CT is lacking owing to limitations of the method. Near-infrared time-resolved spectroscopy (NIRTRS) is a technique for evaluating human BAT density noninvasively. This study aimed to test whether NIRTRS could detect changes in BAT density during or after long-term intervention. First, using FDG-PET/CT, we confirmed a significant increase (+48.8%, P < 0.05) in BAT activity in the supraclavicular region after 6-week treatment with thermogenic capsaicin analogs, capsinoids. Next, 20 volunteers were administered either capsinoids or placebo daily for 8 weeks in a double-blind design, and BAT density was measured using NIRTRS every 2 weeks during the 8-week treatment period and an 8-week period after stopping treatment. Consistent with FDG-PET/CT results, NIRTRS successfully detected an increase in BAT density during the 8-week treatment (+46.4%, P < 0.05), and a decrease in the 8-week follow-up period (-12.5%, P = 0.07), only in the capsinoid-treated, but not the placebo, group. Thus, NIRTRS can be applied for quantitative assessment of BAT in longitudinal intervention studies in humans.

• 出版日期2016-9