A Developmental Switch in Microglial HDAC Function

作者：Mathys Hansruedi; Penney Jay; Tsai Li Huei^*

来源：Immunity, 2018, 48(3): 476-478.

DOI：10.1016/j.immuni.2018.03.010

The epigenetic mechanisms controlling microglia functions are largely unknown. In this issue of Immunity, Datta et al. (2018) uncover surprising and distinct effects of deleting the epigenetic regulators HDAC1 and HDAC2 during microglial development versus during the course of neurodegeneration.

• 出版日期2018-3-20
• 单位MIT