A concise synthesis of the pentacyclic framework of cortistatins

作者：Yamashita Shuji; Iso Kentaro; Hirama Masahiro^*

来源：Organic Letters, 2008, 10(16): 3413-3415.

DOI：10.1021/ol8012099

An efficient synthesis of the pentacyclic framework of cortistatins has been developed. The key strategy comprises assembly of the A- and the CD-ring fragments by Knoevenagel reaction, facile formation of the pyran ring via electrocyclization, and construction of the seven-membered B-ring by radical addition to an alpha,beta-unsaturated ketone.

• 出版日期2008-8-21