科研之友
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摘要
Nanobodies are recombinant, single-domain and variable fragments of camelid heavy chain-only antibodies (similar to 95 kDa) which are able to bind selectively to specific antigens. Nanobodies are variable domain of heavy chain antibodies (i.e., VHH) with approximate molecular weight of 12-15 kDa, considered also as smallest naturally derived antigen-binding fragments. Investigation on VHHs crystal structures revealed them as having a prolate (rugby ball) shape with approximately 2.5 nm in diameter and 4.2 nm in length. The term "nanobody" was given by the Belgian company Ablynx and it refers to the VHH domain from Camelidae species. This current article reviews the molecular background of nanobodies and describes their generation, treatment, diagnosis and other applications.
- 出版日期2016-12
- 单位广西医科大学
