A bidirectional relationship of oral-systemic responses: observations of systemic host responses in patients after full-mouth extractions

作者：Cunningham L L^*; Novak M J; Madsen M; Abadi B; Ebersole J L

来源：Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2014, 117(4): 435-444.

DOI：10.1016/j.oooo.2013.11.502

Objective. This investigation tested the hypothesis that systemic inflammatory responses would be attenuated by minimizing the oral microbial burden in patients with moderate to severe periodontitis. %26lt;br%26gt;Study Design. Patients (n = 73) scheduled for full-mouth extractions were categorized as case type I/II (gingivitis/mild periodontitis) or case type III/IV (moderate/severe periodontitis). Serum levels of acute phase proteins (APPs) and immunoglobulin G (IgG) antibody were assessed at baseline and through 1 year after extraction. %26lt;br%26gt;Results. At baseline, the levels of multiple APPs (e.g., fibrinogen, C-reactive protein) and antibodies to periodontal pathogens were significantly higher with case type III/IV vs I/II. These differences were sustained 12 months after extractions for most APPs. %26lt;br%26gt;Conclusions. The results demonstrated that removal of disease by full-mouth extraction of teeth altered the overall burden of challenge to the host. Continued elevation in various APPs in the III/IV group suggested a potential underlying constitutive difference in systemic response characteristics of this population.

• 出版日期2014-4