Anterograde transport of neurotrophic factors - Possible therapeutic implications

作者：Caleo M^*; Cenni MC

来源：Molecular Neurobiology, 2004, 29(2): 179-195.

DOI：10.1385/MN:29:2:179

• anterograde axonal transport
• neurotrophic factors
• neurotrophin release
• neuronal death
• synaptic transmission
• gene therapy
• neuroprotection
• functional sparing

The actions of neurotrophic factors are classically thought to be mediated by their retrograde transport from target tissues to the cell bodies. There is now evidence that specific trophic factors are trafficked anterogradely along peripheral and central axons and released to postsynaptic cells. This review focuses on recent experiments that demonstrate the involvement of the anterograde transfer of neurotrophic factors in various physiological processes, including the regulation of developmental neuronal death, the modulation of synaptic transmission, and the control of axonal and dendritic architecture. The authors also discuss whether anterograde transport of exogenous trophic factors can be exploited to protect damaged postsynaptic neurons and spare their function. This issue has clear implications for possible therapeutic applications of neurotrophic factors.

• 出版日期2004-4