Vitamin D metabolism and deficiency in critical illness

作者：Lee Paul^*

来源：Best Practice & Research Clinical Endocrinology & Metabolism, 2011, 25(5): 769-781.

DOI：10.1016/j.beem.2011.03.001

• vitamin D
• critical illness
• parathyroid hormone
• hypocalcaemia
• hyperparathyroidism

Vitamin D deficiency is highly prevalent and has been associated with a diverse range of chronic medical conditions in the general population. In contrast, the prevalence, pathogenesis and significance of vitamin D deficiency have received little attention in acute medicine. Vitamin D deficiency is seldom considered and rarely corrected adequately, if at all, in critically ill patients. Recent recognition of the extra-skeletal, pleiotropic actions of vitamin D in immunity, epithelial function and metabolic regulation may underlie the previously under-recognized contribution of vitamin D deficiency to typical co-morbidities in critically ill patients, including sepsis, systemic inflammatory response syndrome and metabolic dysfunction. Improved understanding of vitamin D metabolism and regulation in critical illness may allow therapeutic exploitation of vitamin D to improve outcome in critically ill patients.

• 出版日期2011-10