An Experimental Study on the Bionic Functioned Poly(lactic-co-glycolic acid) Nerve Conduits Used for Peripheral Nerve Regeneration

作者：Rao, Jianwei^*; He, Feixiong; Liu, Yanxiao; Ye, Zhou; Zhan, Beilei^*; Xu, Yangbin; Daping, Quan

来源：Journal of Biomaterials and Tissue Engineering, 2017, 7(3): 175-187.

DOI：10.1166/jbt.2017.1559

• Poly(lactic-co-glycolic acid) (PLGA)
• Silk Fibroin (SF)
• Bionic Functioned
• Peripheral Nerve Regeneration

At least millions of people suffered from peripheral nerve injuries (PNI) annually. The current "gold" standard for treatment of nerve defects is still the autologous nerve grafts, which poses disadvantages such as postoperative complications and limited availability of nerve tissue. These problems have motivated the development of artificial nerve conduits (NCs) which could be used as an alternative to auto-graft. Physical cues in the NCs should direct the sprouting of axons from the proximal nerve end, concentrate growth factors secreted by the injured nerve ends, and reduce the ingrowth of scar tissue into the injury site. In this paper, we developed a novelty bionic designed poly(lactic-co-glycolic acid) (PLGA) NCs which had special physical cues. The hollow PLGA-NCs were fabricated and inserted with linearly oriented silk fibroin (SF) multi-channels as internal skeleton were used for implantation across a 10-mm long sciatic nerve defect in rats, and the outcomes 2 months post-implantation were evaluated by a combination of electrophysiological assessment and histological investigation. The examined functional and morphological parameters showed that the bionic functioned PLGA-NCs could promote peripheral nerve regeneration with effects approaching those elicited by the nerve auto-grafts, which seemed to be a promising candidate for the successful and functional regeneration of the peripheral nerve.

• 出版日期2017-3
• 单位中山大学