Automated preparation of the dopamine D-2/3 receptor agonist ligand [C-11]-(+)-PHNO for human PET imaging studies

作者：Plisson Christophe^*; Huiban Mickael; Pampols Maso Sabina; Singleton Goerkem; Hill Samuel P; Passchier Jan

来源：Applied Radiation and Isotopes, 2012, 70(2): 380-387.

DOI：10.1016/j.apradiso.2011.09.018

• Carbon-11
• Dopamine D3
• Automation
• GMP
• PHNO

Carbon-11 labelled (+)-4-Propy1-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol ([C-11]-(+)-PHNO) is used as a high-affinity state, dopamine D-2/3 receptor ligand in clinical PET studies. To facilitate its use, robust, rapid, efficient and GMP compliant methods are required for the manufacturing and QC testing processes. Additionally, to allow for full quantification of the resulting signal in the CNS, a reliable method is required to establish the parent plasma concentration over the course of the scan. This paper provides high-quality methods to support clinical application of (C-11]-(+)-PHNO.

• 出版日期2012-2