Scalable Gastric Resident Systems for Veterinary Application

作者:Hayward Alison; Bensel Taylor; Mazdiyasni Hormoz; Rogner Jaimie; Kirtane Ameya R; Lee Young Ah Lucy; Hua Tiffany; Bajpayee Ambika; Collins Joy; McDonnell Shane; Cleveland Cody; Lopes Aaron; Wahane Aniket; Langer Robert*; Traverso Giovanni*
来源:Scientific Reports, 2018, 8(1): 11816.
DOI:10.1038/s41598-018-30212-3

摘要

Gastric resident dosage forms have been used successfully in farm animals for the delivery of a variety of drugs helping address the challenge of extended dosing. Despite these advances, there remains a significant challenge across the range of species with large variation in body size. To address this, we investigate a scalable gastric resident platform capable of prolonged retention. We investigate prototypes in dimensions consistent with administration and retention in the stomachs of two species (rabbit and pig). We investigate sustained gastric retention of our scalable dosage form platform, and in pigs show the capacity to modulate drug release kinetics of a model drug in veterinary practice, meloxicam, with our dosage form. The ability to achieve gastric residence and thereby enable sustained drug levels across different species may have a significant impact in the welfare of animals in both research, agricultural, zoological, and clinical practice settings.

  • 出版日期2018-8-7
  • 单位MIT