Stereoselective synthesis of C19-C27 fragment of bryostatin 11

作者：Yadav J S^*; Swamy T; Reddy B V Subba; Ravinder V

来源：Tetrahedron Letters, 2014, 55(30): 4054-4056.

DOI：10.1016/j.tetlet.2014.05.116

• Kinetic resolution
• Grignard reaction
• Sharpless dihydroxylation
• AIBN
• Radical cyclization

A convergent synthesis of C19-C27 fragment (2) of bryostatin-11 is described. The key steps involved in this approach are kinetic resolution, Grignard reaction, and Sharpless dihydroxylation. AIBN catalyzed radical cyclization strategy has been used for the first time to construct the six-membered pyran system.

• 出版日期2014-7-23