An efficient and facile synthesis of polydentate ligand: pyridylpyrimidine-2-amine under solvent-free conditions

作者：Tao Shimin; Xia Sheng; Rong Liangce^*; Cao Changsheng; Tu Shujiang

来源：Research on Chemical Intermediates, 2012, 38(8): 2065-2073.

DOI：10.1007/s11164-012-0526-9

• Polydentate ligand
• Pyridylpyrimidine-2-amine
• Multicomponent reaction
• Solvent-free synthesis
• Green chemistry

An efficient and facile synthesis of polydentate ligand pyridylpyrimidine-2-amine via a one-pot reaction of different aromatic aldehydes, 2-acetylpyridine and guanidine carbonate, in the presence of NaOH under solvent-free conditions, is reported. These compounds have four N-donors and they are classic polydentate ligands of many metal ions. Due to employing a one-pot, multicomponent reaction, this method offers several advantages including easy experimental work-up procedure, and lower cost, short reaction time, and especially high yields of products. This paper therefore develops a practical and convenient process for the synthesis of these ligands.

• 出版日期2012-10
• 单位江苏师范大学