Microwave-assisted multi-step synthesis of novel pyrrolo-[3,2-c]quinoline derivatives

作者：Benakki Hafid; Colacino Evelina; Andre Christophe; Guenoun Farhate; Martinez Jean; Lamaty Frederic^*

来源：Tetrahedron, 2008, 64(25): 5949-5955.

DOI：10.1016/j.tet.2008.04.034

• microwave activation
• Suzuki coupling
• Aza-Baylis-Hillman
• ring-closing metathesis

A new approach for the synthesis of original substituted pyrrolo-[3,2-c]quinoline derivatives using microwave-assisted chemistry is described. The use of microwave activation in this synthesis resulted in high yielding and clean steps. The key step for introducing diversity is the amination or the Pd-catalyzed cross-coupling of an imidoyl chloride derivative, obtained in a straightforward manner and in good yield.

• 出版日期2008-6-16