Maghemite-gold core-shell nanostructures (γ-Fe2O3@Au) surface-functionalized with aluminium phthalocyanine for multi-task imaging and therapy

作者：Coelho, B. C. P.; Siqueira, E. R.; Ombredane, A. S.; Joanitti, G. A.; Chaves, S. B.; da Silva, S. W.; Chaker, J. A.; Longo, J. P. F.; Azevedo, R. B.; Morais, P. C.; Sousa, M. H.^*

来源：RSC Advances, 2017, 7(19): 11223-11232.

DOI：10.1039/c6ra27539g

• MAGNETITE NANOPARTICLES
• PHOTODYNAMIC THERAPY
• CONTRAST AGENTS
• IN-VITRO
• FE3O4-AT-AU NANOPARTICLES
• COMPUTED-TOMOGRAPHY
• OXIDE NANOPARTICLES
• CANCER
• FERROFLUIDS
• CHEMISTRY

In this study we report on the elaboration and characterization of core-shellmaghemite-gold nanoparticles with the shell modulated for different thicknesses below 2 nm. Gold-shelled maghemite nanoparticles with an average core size of about 9 nm were developed using a single-step protocol involving reduction of Au3+ in the presence of citrate-coated maghemite nanoparticles. Additionally, post-functionalization of the core-shell structures with aluminium phthalocyanine was successfully accomplished, aimed at the production of a material platform for photodynamic therapy. The as-produced samples were structurally, morphologically, magnetically and optically characterized and presented long-term colloidal stability at physiological pH. Impressively, we found the as-produced samples showed good X-ray attenuation properties, making them able to be used as nanoprobes for targeted computed tomography. Moreover, in vitro nanocytotoxicity tests confirmed a superior biocompatibility of the as-produced samples, making them a very promising multi-task platform for in vivo applications.

• 出版日期2017
• 单位安徽大学