Anti-inflammatory Amino Acid Derivatives from the Ascidian Herdmania momus

作者：Li, Jian Lin; Han, Sang Chul; Yoo, Eun Sook; Shin, Sook; Hong, Jongki; Cui, Zheng; Li, Huayue; Jung, Jee H.^*

来源：Journal of Natural Products, 2011, 74(8): 1792-1797.

DOI：10.1021/np200397g

Four new amino acid derivatives, herdmanines A-D (1-4), were isolated from the marine ascidian Herdmania momus. Herdmanines A-C contain the unusual D-form of arginine. Compounds 3 and 4 had a moderate suppressive effect on the production of NO, with IC50 values of 96 and 9 mu M, respectively. These compounds were found to inhibit the mRNA expression of iNOS. The inhibitory activities on the production and mRNA expression of pro-inflammatory cytokines such as TNF-alpha, IL-1 beta, and IL-6 were evaluated.

• 出版日期2011-8
• 单位沈阳药科大学