A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and steroid-sensitive nephrotic syndrome in children

作者：Zhou, Tian-Biao^*; Qin, Yuan-Han; Ou, Chao; Su, Li-Na; Lei, Feng-Ying; Huang, Wei-Fang; Zhao, Yan-Jun; Pang, Yu-Sheng

来源：Journal of the Renin-Angiotensin-Aldosterone System, 2012, 13(1): 175-183.

DOI：10.1177/1470320311422579

• Angiotensin converting enzyme (ACE)
• insertion
• deletion (I
• D) gene polymorphism
• meta-analysis
• steroid-sensitive nephrotic syndrome (SSNS)

Background and objective: Angiotensin-converting enzyme (ACE) insertion/ deletion (I/ D) gene polymorphism correlates with circulating and cellular ACE concentration. Association between ACE I/ D gene polymorphism and steroid-sensitive nephrotic syndrome (SSNS) risk in children is still controversial. This meta-analysis was performed to evaluate the relation between ACE I/ D gene polymorphism and SSNS susceptibility in children.
Methods: The relevant investigations were screened from the search engines of PubMed, Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 March 2011, and eligible studies were synthesized using meta-analysis methods.
Results: Ten studies were identified for the analysis of association between ACE I/D gene polymorphism and SSNS risk in children, including seven in Asians, one for Caucasians and two in Africans. There was no markedly positive association between D allele or DD genotype and SSNS susceptibility in Asians, Caucasians and Africans (D: Asians OR = 1.24, p = 0.28; Caucasians OR = 1.61, p = 0.15; Africans OR = 1.61, p = 0.53; DD: Asians OR = 1.72, p = 0.15; Caucasians OR = 1.39, p = 0.48; Africans OR = 1.80, p = 0.56). Furthermore, II homozygous seemed not to play a protective role against SSNS onset for Asians, Caucasians and Africans (Asians OR = 0.95, p = 0.85; Caucasians OR = 0.30, p = 0.11; Africans OR = 0.60, p = 0.65).
Conclusions: There was no association between ACE I/D gene polymorphism and SSNS susceptibility in Asians, Caucasians and Africans. However, the conclusions for Caucasians and Africans were less powerful.

• 出版日期2012-3
• 单位广西医科大学