Association of ADRB1 gene polymorphisms with pain sensitivity in a Chinese population

作者：Feng, Shuang; Li, Nan; Xu, Sheng; Wang, Hao; Yu, Wei; Lu, Yan; Cao, Jianping; Meng, Yan^*

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(7): 11514-11518.

• beta 1-adrenergic receptor
• gene polymorphism
• opioid
• pain
• individual difference

Objective: The present study aims to observe the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain sensitivity. Methods: We analyzed the associations between pain sensitivity and ADRB1 gene SNPs (A145 G and G1165 C) in 324 Chinese patients who underwent surgery. The genotyping was performed using PCR-RFLP technique. Results: The patients who carried the A-allele of the A145 G SNP were more sensitive to cold pressor-induced pain than those who did not carry this allele (P < 0.05). We did not found G1165 C polymorphism associated with pain sensitive in the present study. The haplotype analysis revealed A-C haplotype carriers have reduced fentanyl use in 24-h postoperative (P < 0.05). Conclusion: ADRB1 gene polymorphisms are associated with pain and analgesic sensitivity.

• 出版日期2015
• 单位苏州大学; 中国人民解放军第二军医大学