Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum

作者：Shi, Yan-Ni; Liu, Fang-Fang; Jacob, Melissa R.; Li, Xing-Cong; Zhu, Hong-Tao; Wang, Dong; Cheng, Rong-Rong; Yang, Chong-Ren; Xu, Min^*; Zhang, Ying-Jun^*

来源：Planta Medica, 2017, 83(01-02): 143-150.

DOI：10.1055/s-0042-109778

• Piper flaviflorum
• Piper sarmentosum
• Piperaceae
• amide alkaloids
• antifungal activity

Sixty-three amide alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1E,3S)-1-cinnamoyl-3-hydroxypyrrolidine (3) and N-[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectroscopic analysis and, in case of 3, by single-crystal X-ray diffraction. Most of the isolates were tested for their antifungal and antibacterial activities. Ten amides (6-15) showed antifungal activity against Cryptococcus neoformans ATCC 90113 with IC50 values in the range between 4.7 and 20.0 mu g/mL.

• 出版日期2017-1
• 单位中国科学院昆明植物研究所; 植物化学与西部植物资源持续利用国家重点实验室; 云南中医药大学; 中国科学院大学