A phenylpropanoid glycoside with antioxidant activity from Picria tel-ferae

作者：Thuan Nguyen Duy; Ha Do Thi; Thuong Phuong Thien; Na Min Kyun; Lee Jong Pill; Lee Jeong Hun; Seo Hyo Won; Min Byung Sun^*; Kim Jin Cheol; Bae KiHwan

来源：Archives of Pharmacal Research, 2007, 30(9): 1062-1066.

DOI：10.1007/BF02980238

• Picria tel-ferae
• Scrophulariaceae
• phenylpropanoid glycoside
• antioxidant
• lipid
• peroxidation

A phytochemical study on Picria tel-ferae resulted in the isolation of a phenylpropanoid glycoside (1), which was reported for the first time from this plant. The structure of compound 1 was identified as 1-O-3,4-(dihydroxyphenyl)-ethyl-beta-D-apiofuranosyl-(1 -> 4)-alpha-L-rharmnopyranosyl(1 -> 3)-4-O-caffeoyl-beta-D-glucopyranoside on the basis of spectroscopic analyses. In addition, it was found that 1 exhibited a remarkable inhibitory effect on lipid peroxidation initiated by either a free radical [AAPH; 2,2'-azobis-(2-amidinopropane)dihydrochloride] or generated hydroxyl radical Fe2+/ascorbate). These findings, together with those of previous studies, suggest that P. tel-ferae possesses abundant phenylpropanoid glycosides, and the plant might be used beneficially in the treatment of oxidative stress-related human diseases.

• 出版日期2007-9
• 单位河北医科大学