A unique polymeric nano-carrier for anti-tuberculosis therapy

作者:Mane Shivshankar R; Rao Vijayakameswara N; Chatterjee Koushik; Dinda Himadri; Nag Soma; Kishore Abhinoy; Das Sarma Jayasri*; Shunmugam Raja
来源:Journal of Materials Chemistry, 2012, 22(37): 19639-19642.
DOI:10.1039/c2jm33860b

摘要

A nano-carrier made of a norbornene derived isoniazid copolymer is designed. In vitro cytotoxicity assay and renal clearance analysis clearly indicate that the newly designed nano-carrier is biocompatible in nature. This nano-carrier with a hydrazone linker is shown to be a promising reservoir with excellent performance for an efficient drug delivery system. Moreover, the system also offers an effective strategy and new modalities for the development of TB therapy.

  • 出版日期2012