Bloodstream Infections During the First Year After Pediatric Small Bowel Transplantation

作者：Florescu Diana F^*; Qiu Fang; Langnas Alan N; Mercer David F; Chambers Heather; Hill Lisa A; Qaragholi Noor; Kalil Andre C

来源：Pediatric Infectious Disease Journal, 2012, 31(7): 700-704.

DOI：10.1097/INF.0b013e318256f9c3

• bacteremia
• fungemia
• bloodstream infections
• pediatric
• intestinal
• small bowel
• transplant

Background: Little information regarding bloodstream infections (BSIs) in small bowel transplantation has been published. %26lt;br%26gt;Methods: We reviewed the medical records of 98 pediatric patients who underwent small bowel transplantation. Patients%26apos; characteristics were analyzed with Wilcoxon rank-sum, chi(2) or Fisher%26apos;s exact tests. We estimated the overall survival by the Kaplan-Meier method and compared survival distributions between groups with the log-rank test. %26lt;br%26gt;Results: Sixty-eight patients developed %26gt;= lepisode of BSIs (total of 146 episodes), and 69.1% of the first infections were diagnosed in the 3 months post-transplantation. The most common sources of infection were as follows: central venous catheters (49.3%) and intra-abdominal infections (32.9%). Central venous catheters were present in 86.3%, and total parenteral nutrition within 7 days before infection was administered in 72.6% of episodes. Gram-positive bacteria (96 isolates) were more frequently isolated than Gram-negative bacteria (52 isolates), with Enterococcus spp. being the most commonly identified (48 isolates), followed by coagulase-negative Staphylococcus (40 isolates). Patients with infections were younger than those without (median 1.4 versus 2.1 years, P = 0.02). Four grafts were lost after transplantation in patients with BSIs and 2 in patients without BSIs (P = 0.99). One-year survival rate for patients without BSIs was 86.7% (95% confidence interval: 68.3%-94.8%) versus 72.1% in patients with BSIs (95% confidence interval: 59.8%-81.2%). Overall time to death was shorter in patients with BSIs than in patients without BSIs (P - 0.056). %26lt;br%26gt;Conclusions: Almost 70% of small bowel transplantation recipients developed BSIs, mainly in the early months after transplantation. BSIs were mainly from a central venous catheter or intra-abdominal source. Enterococcus spp were the most frequently isolated organisms. Patients with BSIs had worse survival than patients with BSIs.

• 出版日期2012-7