A novel hexahydroquinazolin-2-amine-based fluorescence sensor for Cu2+ from isolongifolanone and its biological applications

作者：Wang, Zhonglong; Yang, Jinlai; Yang, Yiqin; Fang, Hua; Xu, Xu; Rui, Jian; Su, Fan; Xu, Haijun; Wang, Shifa^*

来源：RSC Advances, 2017, 7(53): 33263-33272.

DOI：10.1039/c7ra04484d

• NAKED-EYE DETECTION
• COPPER-ION
• FE3+ IONS
• PROBE
• CHEMOSENSOR
• SESQUITERPENES
• DERIVATIVES
• COMPLEXES
• MECHANISM

Pyrimidine-based derivatives 2a-2c were synthesized from renewable isolongifolanone, and compound 2c exhibited high selectivity and sensitivity toward Cu2+ ions with a low detection limit of 4 x 10(-8) M, a wide pH range (5-11), and a short response time (30 s). The sensor still retained good fluorescence selectivity to Cu2+ ions when applied to fluorescence imaging in living black mice. Therefore, compound 2c can be used as an effective fluorescence probe and imaging agent for detecting Cu2+ ions.

• 出版日期2017
• 单位南京林业大学