Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression

作者：Zhang, Lin; Li, Kailong; Zhang, Chengqi; Qi, Xianlong; Zheng, Ning; Wang, Guangbin^*

来源：Open Medicine, 2018, 13(1): 90-95.

DOI：10.1515/med-2018-0014

• autism spectrum disorder
• diffusion tensor imaging
• language regression
• language-related white matter tract
• toddler

Language regression is observed in a subset of toddlers with autism spectrum disorder (ASD) as initial symptom. However, such a phenomenon has not been fully explored, partly due to the lack of definite diagnostic evaluation methods and criteria. Materials and Methods: Fifteen toddlers with ASD exhibiting language regression and fourteen age-matched typically developing (TD) controls underwent diffusion tensor imaging (DTI). DTI parameters including fractional anisotropy (FA), average fiber length (AFL), tract volume (TV) and number of voxels (NV) were analyzed by Neuro 3D in Siemens syngo workstation. Subsequently, the data were analyzed by using IBM SPSS Statistics 22. Results: Compared with TD children, a significant reduction of FA along with an increase in TV and NV was observed in ASD children with language regression. Note that there were no significant differences between ASD and TD children in AFL of the arcuate fasciculus (AF). Conclusions: These DTI changes in the AF suggest that microstructural anomalies of the AF white matter may be associated with language deficits in ASD children exhibiting language regression starting from an early age.

• 出版日期2018
• 单位济宁医学院; 山东省千佛山医院; 山东大学; 山东省医学影像学研究所