A metal-free one-pot cascade synthesis of highly functionalized biaryl-2-carbaldehydes

作者：Challa Chandrasekhar; Vellekkatt Jamsheena; Ravindran Jaice; Lankalapalli Ravi S^*

来源：Organic and Biomolecular Chemistry, 2014, 12(43): 8588-8592.

DOI：10.1039/c4ob01829j

A metal-free one-pot cascade annulation of acyclic substrates dienaminodioate, cinnamaldehydes and allyl amine was achieved for the synthesis of polyfunctional biaryl-2-carbaldehydes. The reaction proceeds at room temperature by a trifluoroacetic acid mediated Diels-Alder pathway. Synthetic applications of the resulting biaryl-2-carbaldehyde have been demonstrated by conversion into an array of diverse molecules with biological and materials chemistry relevance. The present work offers a complementary route to the existing metal mediated cross-coupling methods for the preparation of biaryls.

• 出版日期2014