Acrodermatitis Continua of Hallopeau Is a Clinical Phenotype of DITRA: Evidence that It Is a Variant of Pustular Psoriasis

作者：Abbas Ossama; Itani Salam; Ghosn Samer; Kibbi Abdul Ghani; Fidawi Georges; Farooq Muhammad; Shimomura Yutaka; Kurban Mazen^*

来源：Dermatology, 2013, 226(1): 28-31.

DOI：10.1159/000346572

• Acrodermatitis continua of Hallopeau
• Generalized pustular psoriasis
• IL36RN gene
• Mutations

Acrodermatitis continua of Hallopeau (ACH) is a rare, chronic, sterile, pustular eruption that predominantly affects the fingertips with nail involvement. While some consider ACH a distinct entity, many believe it to be a variant of pustular psoriasis, especially as cases of ACH progressing to generalized pustular psoriasis (GPP) have been reported. Recently, recessively inherited mutations in the IL36RN gene, which encodes interleukin-36 receptor antagonist (IL-36Ra), have been demonstrated to be the cause of familial GPP, a condition termed DITRA (deficiency of IL-36Ra). Here, we identified a homozygous missense mutation c.338C%26gt;T (p.Ser113Leu) in the IL36RN gene in a male patient with ACH, as well as in his sister who had a history of GPP.

• 出版日期2013