Molecular diagnosis and precision medicine in allergy management

作者：Riccio Anna Maria; De Ferrari Laura; Chiappori Alessandra; Ledda Sabina; Passalacqua Giovanni; Melioli Giovanni; Canonica Giorgio Walter

来源：Clinical Chemistry and Laboratory Medicine, 2016, 54(11): 1705-1714.

DOI：10.1515/cclm-2016-0007

• allergen immunotherapy
• computer-supported allergy diagnostics
• molecular based allergen diagnostics
• multiplexed allergy diagnosis
• precision medicine
• single-plexed allergy diagnosis

Precision medicine (PM) can be defined as a structural model aimed at customizing healthcare, with medical decisions/products tailored on an individual patient at a highly detailed level. In this sense, allergy diagnostics based on molecular allergen components allows to accurately define the patient's IgE repertoire. The availability of highly specialized singleplexed and multiplexed platforms support allergists with an advanced diagnostic armamentarium. The therapeutic intervention, driven by the standard diagnostic approach, but further supported by these innovative tools may result, for instance, in a more appropriate prescription of allergen immunotherapy (AIT). Also, the phenotyping of patients, which may have relevant effects on the treatment strategy, could be take advantage by the molecular allergy diagnosis.

• 出版日期2016-11