Mechanisms and functions for the duration of intercellular contacts made by lymphocytes

作者：Davis Daniel M^*

来源：Nature Reviews Immunology, 2009, 9(8): 543-555.

DOI：10.1038/nri2602

Communication across intercellular contacts is central to establishing appropriate innate and adaptive immune responses. Recent imaging of lymphocyte interactions suggests that a complex orchestration of cell-cell contact times is a key correlate to establishing appropriate immune responses. Here I review the molecular and cellular processes that influence the duration of intercellular contacts, including integrin activation and dynamic changes in membrane morphology. I discuss how these processes can be regulated, for example, by the balance of activating and inhibitory receptor signals, and how they can establish the appropriate outcome for individual cell-cell interactions.

• 出版日期2009-8