Analysis of gastrin-releasing peptide gene and gastrin-releasing peptide receptor gene in patients with agoraphobia

作者：Zimmermann Katrin; Goergens Heike; Braeuer David; Einsle Franziska; Noack Barbara; von Kannen Stephanie; Grossmann Maria; Hoyer Juergen; Strobel Alexander; Koellner Volker; Weidner Kerstin; Ziegler Andreas; Hemmelmann Claudia; Schackert Hans K

来源：Psychiatric Genetics, 2014, 24(5): 232-233.

DOI：10.1097/YPG.0000000000000038

• agoraphobia
• gastrin-releasing peptide gene
• gastrin-releasing peptide receptor
• genetic variants
• panic disorder
• sequence analysis

A gastrin-releasing peptide receptor (GRPR) knock-out mouse model provided evidence that the gastrin-releasing peptide (GRP) and its neural circuitry operate as a negative feedback-loop regulating fear, suggesting a novel candidate mechanism contributing to individual differences in fear-conditioning and associated psychiatric disorders such as agoraphobia with/without panic disorder. Studies in humans, however, provided inconclusive evidence on the association of GRP and GRPR variations in agoraphobia with/without panic disorder. Based on these findings, we investigated whether GRP and GRPR variants are associated with agoraphobia. Mental disorders were assessed via the Munich-Composite International Diagnostic Interview (M-CIDI) in 95 patients with agoraphobia with/without panic disorder and 119 controls without any mental disorders. A complete sequence analysis of GRP and GRPR was performed in all participants. We found no association of 16 GRP and 7 GRPR variants with agoraphobia with/without panic disorder.

• 出版日期2014-10
• 单位河北医科大学