New phenolic glycosides with cyclooxygenase inhibition from the roots of Tecoma mollis

作者：Abdel Mageed Wael M^*; Al Wahaibi Lamya H; Backheet Enaam Y; El Gamal Ali A; Gouda Yaser G; Basudan Omer A; Abdel Kader Maged S; Khalifa Azza A

来源：Phytochemistry Letters, 2017, 21: 98-103.

DOI：10.1016/j.phytol.2017.06.011

• Tecoma mollis
• Phenolic glycosides
• Phenylpropanoids
• Radical scavenging activity
• Cycloxygenase inhibition activity
• Cytotoxicity

Three new phenolic glycosides (1-3) together with nine known ones were isolated from the roots of Tecoma mollis using DPPH radical scavenging bioassay-guided chromatographic separation. The structures of the new compounds were established using extensive spectroscopic data and HR-MS. The antioxidant, COX-2 inhibition, and cytotoxic activities were evaluated for the isolated compounds. Compound 4 displayed the strongest radical scavenging activity relative to ascorbic acid with IC5(0) 8.7 mu M. Compounds 5, 6, and 10 showed promising COX-2 inhibitory action, IC50 values of 11.3 mu M, 9.4 mu M, and 13.4 mu M, respectively. All compounds exhibited weak cytotoxic activity against Hela and A549 cancer cell lines.

• 出版日期2017-9