Doxorubicin loaded PEG-b-poly(4-vinylbenzylphosphonate) coated magnetic iron oxide nanoparticles for targeted drug delivery

作者：Halupka Bryl Magdalena^*; Bednarowicz Magdalena; Dobosz Bernadeta; Krzyminiewski Ryszard; Zalewski Tomasz; Wereszczynska Beata; Nowaczyk Grzegorz; Jarek Marcin; Nagasaki Yukio

来源：Journal of Magnetism and Magnetic Materials, 2015, 384: 320-327.

DOI：10.1016/j.jmmm.2015.02.078

• Iron oxide nanoparticles
• Superparamagnetism
• Electron spin resonance
• Magnetic resonance
• Drug delivery

Due to their unique physical properties, superparamagnetic iron oxide nanoparticles are increasingly used in medical applications. They are very useful carriers for delivering antitumor drugs in targeted cancer treatment. Magnetic nanoparticles with chemiotherapeutic were synthesized by coprecipitation method followed by coaling with biocompatible polymer. The aim of this work is to characterize physical and magnetic properties of synthesized nanoparicles. Characterization was carried out using EPR, HRTEM, X-ray diffraction, SQUID and NMR methods. The present findings show that synthesized nanosystem is promising tool for potential magnetic drug delivery.

• 出版日期2015-6-15