Glycine propionyl L-carnitine attenuates D-Galactosamine induced fulminant hepatic failure in wistar rats

作者：Ganai Ajaz A; Jahan Sadaf; Ahad Amjid; Abdin M Z; Farooqi Humaira^*

来源：Chemico-Biological Interactions, 2014, 214: 33-40.

DOI：10.1016/j.cbi.2014.02.006

• Liver damage
• Inflammation
• Lipid peroxidation
• Oxidative stress

Glycine propionyl L-carnitine (GPLC) is a propionyl ester of carnitine that includes an additional glycine component. The present study evaluated hepatoprotective effect of GPLC in D-Galactosamine (D-GalN) induced fulminant hepatic failure. Rats were intraperitonially administered D-GalN (700 mg/kgBW). GPLC was given as a pre-treatment (35 mg/kgBW/day) for 1 month followed by a single dose of D-GalN on the 31st day. D-GalN administration resulted in increased mortality and serum ALT and AST activities. These increases were significantly attenuated by GPLC. D-GalN treatment increased hepatic lipid peroxidation and a decrease in reduced glutathione content was observed. GPLC pre-treatment significantly decreased lipid peroxidation and augmented the level of GSH. D-GalN increased the circulating level of TNF-alpha and ATM-Kinase and MAP-Kinase expression. GPLC supplementation inhibited the increase in serum TNF-a and ATM-Kinase and MAP-Kinase expression. D-GaIN treatment increased the level of Bax and Caspase-3 m-RNA while as a decline was observed in Bcl2 m-RNA. GPLC prevented the increase in Caspase-3 and Bax m-RNA and at the same time augmented the expression of Bcl2 m-RNA. Our findings suggest that GPLC alleviates D-GaIN induced liver injury by strengthening antioxidative defense system and reducing apoptotic signalling pathways.

• 出版日期2014-5-5