摘要

1. Although the major pathways involved in drug metabolism have been elucidated, there remain those routes that may be considered as minor, esoteric, or even artifactual. <br xmlns:set="http://exslt.org/sets">2. Conjugation with urea, an abundant, non-toxic, small water soluble molecule, is such a disputed and debatable Phase II pathway. 3. The present article collates data gleaned from the literature concerning xenobiotic-urea conjugation, presents pertinent information resurrecting the controversy and poses questions as to the nature of the phenomenon.

  • 出版日期2014-12