Anticancer potential of animal venoms and toxins

作者：Gomes Antony; Bhattacharjee Pushpak; Mishra Roshnara; Biswas Ajoy K; Dasgupta Subir Chandra; Giri Biplab; Debnath Anindita; Das Gupta Shubho; Das Tanaya; Gomes Aparna

来源：Indian Journal of Experimental Biology, 2010, 48(2): 93-103.

• Anticancer activity
• Combination therapy
• Toxins
• Venoms

Anticancer drug development from natural resources are ventured throughout the world. Animal venoms and toxins a potential bio resource and a therapeutic tool were known to man for centuries through Folk and traditional knowledge. The biodiversity of venoms and toxins made it a unique Source of leads and structural templates from which new therapeutic agents may be developed. Venoms of several animal species (snake, scorpion, toad, frog etc) and their active components (protein and non protein toxins, peptides, enzymes, etc) have shown therapeutic potential against cancer. In the present review, the anticancer potential of venoms and toxins from snakes, scorpions, toads and frogs has been discussed. Some of these molecules are in the clinical trials and may Find their way towards anticancer drug development in the near future. The implications of combination therapy of natural products in cancer have been discussed.

• 出版日期2010-2