Approaches to the Syntheses of Partially Reduced Imidazo[1,2-a]pyridines

作者：Shin Junhwa^*; Nho Young Chang; Howard Arthur S

来源：Bulletin of the Korean Chemical Society, 2008, 29(10): 1998-2004.

• Aza-alkaloid
• Heterocyclic compounds
• Indolizidine

Two synthetic pathways to substituted hexahydroimidazo[1,2-a]pyridines, which may serve as precursors of aza-alkaloids, were investigated. The first involves the condensation of a bisnucleophilic enediaminoester and a biselectrophile. The second involves attachment to nitrogen of the carbon chain skeleton required to form the six-memberd ring, before formation of the enediaminoester. Several substituted hexahydroimidazo[1,2-a]pyridines were synthesized via these two approaches.

• 出版日期2008-10