Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis

作者:Lefeuvre Sandrine; Marchand Sandrine; Pariat Claudine; Lamarche Isabelle; Couet William*
来源:Antimicrobial Agents and Chemotherapy, 2008, 52(4): 1516-1518.
DOI:10.1128/AAC.01474-07

摘要

Imipenem distribution was characterized by microdialysis in the peritoneal fluid of rats with experimental pancreatitis. The ratios of peritoneal fluid to blood area under unbound concentration-versus-time curves were close to unity, suggesting that imipenem was not degraded in peritoneal fluid.

  • 出版日期2008-4