Acasiane A and B and Farnesirane A and B, Diterpene Derivatives From the Roots of Acacia farnesiana

作者：Lin, An Shen; Lin, Chia Rong; Du, Ying Chi; Luebken, Tilo; Chiang, Michael Y; Chen, I Hsiao; Wu, Chin Chung; Hwang, Tsong Long; Chen, Shu Li; Yen, Ming Hong; Chang, Fang Rong; Wu, Yang Chang^*

来源：Planta Medica, 2009, 75(3): 256-261.

DOI：10.1055/s-0028-1112201

• Mimosoideae
• Acacia farnesiana
• cassane diterpene
• betulinic acid
• cytotoxicity
• anti-inflammatory

Four new diterpenes, acasiane A (1), acasiane B (2), farnesirane A (3), and farnesirane B (4), along with three known diterpenes (5-7), two triterpenes (8 and 9), and eight flavonoids (10-17) were isolated from the roots of Acacia farnesiana. The structures and relative configurations of these compounds were determined by various spectroscopic and x-ray analyses. All isolated compounds were evaluated for their in vitro cytotoxic activities against six human cancer cell lines (Hep G2, Hep 313, MIDA-MB-231, MCF-7, A549, and Ca9-22) with the MTT method. Betulinic acid (8) displayed moderate cytotoxicity (1.70-5.74 mu g/mL) towards five human cancer cell lines and the flavonoids had slight effects. In addition, 8, diosmetin (13), and 3',4',5-trihydroxy-7-methoxyflavone (15) slightly inhibited superoxide anion generation or elastase release by human neutrophils, indicating moderate anti-inflammatory activities.

• 出版日期2009-2
• 单位长春大学; 中山大学